It is currently perfectly founded that PAIs comprise a sizable loved ones of cellular genetic elements and may go through horizontal transfer to a different host species (Sakellaris et al
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ORF, which encodes a hypothetical protein of mysterious functionality. The course of transfer is proven by a horizontal arrow. The reduced percentage of this determine demonstrates the alignment in the 89K oriT
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These observations suggest the 89K-encoded integrase and excisionase probable cooperatively generate the extrachromosomal circular kind of 89K, which represents an intermediate needed for the transfer approach by itself.
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A much better here knowledge of the molecular biology of 89K will unquestionably give crucial Perception in the emergence, virulence, and evolution of the vital pathogen. In fact, it may expose some clues regarding the molecular pathogenesis of STSS because of S. suis
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In summary, the loss of 89K PAI may possibly emphasize the emergence of an epidemic SS2 populace. This inhabitants appears to have genetic heterogeneity that may be undergoing evolution in an adaption to some assortment force in the natural environment, host restriction, or the two.
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) associated with the DNA processing are marked by open up arrows (not drawn to scale). The shaded locations suggest the conserved domains encoded therein, with the internal consensus motifs indicated by black rectangles.
strain BM407, which was isolated from a human meningitis scenario in Vietnam in 2004, includes two regions with prolonged similarity to 89K (Holden et al